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  • 01. Mensaje de los coordinadores

  • 02. Avances en el conocimiento de la farmacología

  • 03. Impacto de Kevzara sobre los PROs
    Eficacia de Kevzara ¿que hay de nuevo?

  • 04. IL6: su importancia en la patogenia de la artitis reumatoide


La IL-6 es una citocina multifuncional que puede influir sobre las funciones de una amplia variedad de células y procesos fisiológicos1-4

Los niveles normales de citocinas y de otras moléculas de señalización son un requisito para la homeostasis de los procesos inflamatorios.1,5

Muchas citocinas —incluidos el factor de necrosis tumoral-α (tumor necrosis factor-α, TNF-α), las interleucinas (IL) 1, 4, 6, 12, 13, 17 y 21, y los interferones (IFN)— desempeñan una función clave en las enfermedades inflamatorias.1,6

La IL-6 es un punto crítico en la red de citocinas inflamatorias. En condiciones de autoinmunidad e inflamación crónica, los niveles elevados de IL-6 pueden afectar a la homeostasis de múltiples procesos fisiológicos y contribuir a la inflamación crónica y progresión de la enfermedad.1-4,7-12


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  4. Rho YH, Chung CP, Oeser A, et al. Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum. 2009;61(11)1580-1585.
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  10. Bode JG, Albrecht U, Häussinger D, Heinrich PC, Schaper F. Hepatic acute phase proteins—regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kB-dependent signaling. Eur J Cell Biol. 2012;91(6-7):496-505.
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  12. Raison CL, Borisov AS, Majer M, et al. Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Pyschiatry. 2009;65(4):296-303.
  13. Frank SA. Input-output relations in biological systems: measurement, information and the Hill equation. Biol Direct. 2013;8(31):1-25.
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  19. Sundgren-Andersson AK, Ostlund P, Bartfai T. IL-6 is essential in TNF-alpha-induced fever. Am J Physiol. 1998;275(6 pt 2):R2028-R2034.
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  21. Mastorakos G, Chrousos GP, Weber JS. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab. 1993;77(6):1690-1694.
  22. Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc Immunol Rev. 2006;12:6-33.
  23. Desgeorges A, Gabay C, Silacci P, et al. Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid. J Rheumatol. 1997;24(8):1510-1516.
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  27. Jansen JH, Kluin-Nelemans JC, Van Damme J, Wientjens GJ, Willemze R, Fibbe WE. Interleukin 6 is a permissive factor for monocytic colony formation by human hematopoietic progenitor cells. J Exp Med. 1992;175(4):1151-1154.
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  30. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med. 1993;119(8):771-778.
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  33. Usón J, Balsa A, Pascual-Salcedo D, et al. Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol. 1997;24(11):2069-2075.
  34. Hein GE, Köhler M, Oelzner P, Stein G, Franke S. The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. Rheumatol Int. 2005;26(2):137-141.
  35. Sacerdote P, Carrabba M, Galante A, Pisati R, Manfredi B, Panerai AE. Plasma and synovial fluid interleukin-1, interleukin-6 and substance P concentrations in rheumatoid arthritis patients: effect of the nonsteroidal anti inflammatory drugs indomethacin, diclofenac and naproxen. Inflamm Res. 1995;44(11):486-490.
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  38. Ito A, Itoh Y, Sasaguri Y, Morimatsu M, Mori Y. Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. Arthritis Rheum. 1992;35(10):1197-1201.
  39. Okada A, Yamasaki S, Koga T, et al. Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis. Clin Exp Rheumatol. 2012;30(3):332-337.
  40. Schmitt RM, Bruyns E, Snodgrass HR. Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes Dev. 1991;5(5):728-740.
  41. Crofford LJ, Kalogeras KT, Mastorakos G, et al. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab. 1997;82(4):1279-1283.

En el siguiente tutorial, la Enfermera Clínica del Área Integrada Aparato Locomotor del Hospital Sant Joan Despí Moisès Broggi, Silvia García Díaz, nos muestra la correcta administración subcutánea de terapias biológicas para pacientes con Artritis Reumatoide.